To retain the structure and function of such compounds, biphasic systems with two water-rich phases are preferable to those with one aqueous and one organic phase. Many types of biotechnological interest molecules, such as proteins, peptides, and other tiny bioactive compounds, could be extracted and recovered using systems comprising two liquid phases at certain critical concentrations 1, 2. These results were in good agreement with the trend of extraction efficiencies of studied drugs. Furthermore, the interaction of mentioned drugs with polyethylene glycol was investigated employing quantum computing techniques based upon density functional theory (DFT). The Diamond-Hsu equation and its modified version were used to correlate the drugs experimental partition coefficients. The trend of extraction efficiencies indicated that the responsibility of extraction of the mentioned drugs into the polymer-rich top phase is related to their hydrophobicity. ![]() For this purpose, partition coefficients and extraction efficiencies of each drug were calculated. Also, the extraction of two analgesic drugs, namely ibuprofen and acetaminophen were investigated by the mentioned ATPS. The consistency of the experimental tie-line data was determined by utilizing the Othmer-Tobias, Bancraft, and Setschenow correlations. ![]() The experimental binodal data were described using two empirical nonlinear three parameter expressions developed by Merchuk and Zafarani-Moattar. ![]() In this work, an aqueous two phase system was made by polyethylene glycol 600 and potassium hydroxide and phase diagram were determined for this system. In recent decades, aqueous two phase systems have gained a lot of attention for extraction of different materials.
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